| Date | Vs. | | Score | Summary | WP | LP | SV | Record | GA/GB |
| 4/4 | at BAL | L | 2-7 | Pedro struggles in the cold | Ponson | P. Martinez | Ryan | 0-1 | -1.0 |
| 4/6 | at BAL | W | 4-1 | Schilling and Foulke shine in Sox debuts | Schilling | DuBose | Foulke | 1-1 | -0.5 |
| 4/7 | at BAL | W | 10-3 | Offense kicks into gear | Lowe | Ainsworth | | 2-1 | +0.5 |
| 4/8 | at BAL | L | 2-3 (13) | Bobby Jones walks in winning run in 13th | R. Lopez | Jones | | 2-2 | -0.5 |
| 4/9 | TOR | L | 5-10 | Sox lose home opener after late flight | Speier | Timlin | | 2-3 | -1.0 |
| 4/10 | TOR | W | 4-1 | Ortiz and Ramirez both homer | P. Martinez | Halladay | Foulke | 3-3 | 0 |
| 4/11 | TOR | W | 6-4 (11) | Ortiz hits Easter walk-off into Monster seats | Malaska | R. Lopez | | 4-3 | 0 |
| 4/15 | BAL | L | 7-12 (11) | Defense falters in 11th | Groom | Arroyo | | 4-4 | -0.5 |
| 4/16 | NYY | W | 6-2 | Redemption: Wakefield wins "Game 8" | Wakefield | Vazquez | | 5-4 | 0 |
| 4/17 | NYY | W | 5-2 | Schilling dominates for 2nd win | Schilling | Mussina | | 6-4 | 0 |
| 4/18 | NYY | L | 3-7 | Lowe rusty after layoff due to rainouts | Quantrill | Lowe | | 6-5 | -1.0 |
| 4/19 | NYY | W | 5-4 | Patriot's Day rally wins it for Sox | Timlin | Gordon | Foulke | 7-5 | -0.5 |
| 4/20 | at TOR | W | 4-2 | Pedro beats Roy Halladay again | P. Martinez | Halladay | Foulke | 8-5 | -0.5 |
| 4/21 | at TOR | W | 4-2 | Mirabelli homers twice | Wakefield | Lilly | Foulke | 9-5 | +0.5 |
| 4/22 | at TOR | L | 3-7 | Schilling gives up grand slam in 8th | Adams | Schilling | | 9-6 | -0.5 |
| 4/23 | at NYY | W | 11-2 | Jose Contreras is no match for Sox bats | Lowe | Contreras | | 10-6 | -0.5 |
| 4/24 | at NYY | W | 3-2 (12) | Bullpen shuts out Yankees for 6 innings | Foulke | Quantrill | Timlin | 11-6 | +0.5 |
| 4/25 | at NYY | W | 2-0 | Pedro completes the sweep | P. Martinez | Vazquez | Williamson | 12-6 | +1.5 |
| 4/28 | TB | W | 6-0 | Six runs more than enough for Schilling | Schilling | Abbott | | 13-6 | +2.0 |
| 4/29 | TB | W | 4-0 | Third straight shutout for Sox pitching | Kim | Zambrano | | 14-6 | +2.0 |
| 4/29 | TB | W | 7-3 | Shutout streak ends in nightcap, but Sox score 7 in
1st inning | Lowe | Moss | | 15-6 | +2.5 |
| Date | Vs. | | Score | Summary | WP | LP | SV | Record | GA/GB |
| 5/1 | at TEX | L | 3-4 | Bullpen's scoreless streak ends at 32 innings | Ramirez | Malaska | Cordero | 15-7 | +3.0 |
| 5/1 | at TEX | L | 5-8 | Rangers sweep double header | Benoit | P. Martinez | Cordero | 15-8 | +2.5 |
| 5/2 | at TEX | L | 1-4 | Sox swept in Texas | Dickey | Wakefield | Cordero | 15-9 | +1.5 |
| 5/3 | at CLE | L | 1-2 | Jake Westbrook and Indians edge Schilling | Westbrook | Schilling | Betancourt | 15-10 | +1.0 |
| 5/4 | at CLE | L | 6-7 | Sox lose 5th straight | Davis | Lowe | Betancourt | 15-11 | 0 |
| 5/5 | at CLE | W | 9-5 | Ortiz homers twice to stop losing streak | Arroyo | D'Amico | | 16-11 | 0 |
| 5/6 | at CLE | W | 5-2 | Manny's homer helps Pedro win | P. Martinez | Sabathia | Foulke | 17-11 | +1.0 |
| 5/7 | KC | W | 7-6 | Bellhorn's HR and Tek's triple win it in 9th | Timlin | MacDougal | | 18-11 | +2.0 |
| 5/8 | KC | W | 9-1 | Pokey has 2 HR, including one inside-the-park, and
Curt pitches complete game | Schilling | Gobble | | 19-11 | +2.0 |
| 5/9 | KC | L | 4-8 | Lowe takes the loss | May | Lowe | | 19-12 | +1.0 |
| 5/10 | CLE | L | 6-10 | Kim is shaky and bullpen lets it get away | Durbin | Kim | | 19-13 | +0.5 |
| 5/11 | CLE | W | 5-3 | Pedro strikes out 11 | Embree | Jimenez | Foulke | 20-13 | +0.5 |
| 5/12 | CLE | L | 4-6 | Sox commit three more errors | Lee | Wakefield | | 20-14 | +0.5 |
| 5/13 | at TOR | L | 6-12 | Jays score 9 runs in last 3 innings | Batista | Schilling | | 20-15 | -0.5 |
| 5/14 | at TOR | W | 9-3 | Sox get revenge with 6 runs in the 8th | Embree | Ligtenberg | | 21-15 | -0.5 |
| 5/15 | at TOR | W | 4-0 | Youkilis homers in ML debut; Arroyo pitches gem | Arroyo | Hentgen | | 22-15 | +0.5 |
| 5/16 | at TOR | L | 1-3 | Halladay finally beats Pedro | Halladay | P. Martinez | Adams | 22-16 | -0.5 |
| 5/18 | at TB | W | 7-3 | Wakefield wins one for his new son, Trevor | Wakefield | Hendrickson | | 23-16 | +0.5 |
| 5/19 | at TB | W | 4-1 | Manny's homer leads Sox past Rays | Schilling | Bell | Foulke | 24-16 | +0.5 |
| 5/20 | at TB | L | 6-9 | Lowe can't get out of 3rd, tagged for 7 runs | Sosa | Lowe | Baez | 24-17 | -0.5 |
| 5/21 | TOR | W | 11-5 | Ramirez breaks tie in 8th | Timlin | Nakamura | | 25-17 | +0.5 |
| 5/22 | TOR | W | 5-2 | Manny's homer gets the comeback started again | A. Martinez | Ligtenberg | Foulke | 26-17 | +1.5 |
| 5/23 | TOR | W | 7-2 | Wakefield scatters 7 singles | Wakefield | Batista | | 27-17 | +1.5 |
| 5/25 | OAK | W | 12-2 | Sox get 19 hits off Tim Hudson | Schilling | Hudson | | 28-17 | +1.5 |
| 5/26 | OAK | W | 9-6 | A's errors give Sox gift win | Lowe | Redman | Foulke | 29-17 | +1.5 |
| 5/27 | OAK | L | 2-15 | A's get 15 runs on 19 hits | Mulder | Arroyo | | 29-18 | +0.5 |
| 5/28 | SEA | W | 8-4 | Manny and Big Papi both homer | P. Martinez | Pineiro | | 30-18 | +0.5 |
| 5/29 | SEA | L | 4-5 | Another Manny homer isn't enough | Garcia | Wakefield | Guardado | 30-19 | -0.5 |
| 5/30 | SEA | W | 9-7 (12) | Curt takes perfect game into 6th; Foulke blows his
1st save; Andy Dominique's 1st ML hit ties the
game; McCarty's homer in 12th wins it | A. Martinez | Ligtenberg | | 31-19 | +0.5 |
| 5/31 | BAL | L | 4-13 | Lowe gives up 7 runs; Sox lose makeup game | R. Lopez | Lowe | | 31-20 | 0 |
| Date | Vs. | | Score | Summary | WP | LP | SV | Record | GA/GB |
| 6/1 | at ANA | L | 6-7 | Vladimir Guerrero's double breaks the tie | Gregg | Arroyo | Percival | 31-21 | -1.0 |
| 6/2 | at ANA | L | 7-10 | Guerrero has 9 RBI; Sox bullpen blows lead | Ortiz | Timlin | Rodriguez | 31-22 | -2.0 |
| 6/4 | at KC | L | 2-5 | Jimmy Gobble retires 15 straight | Gobble | Wakefield | Affeldt | 31-23 | -3.5 |
| 6/5 | at KC | W | 8-4 | Schilling snaps Sox' skid | Schilling | May | | 32-23 | -2.5 |
| 6/6 | at KC | W | 5-3 | Sox rally for 5 runs in 6th | Lowe | Grimsley | Foulke | 33-23 | -2.5 |
| 6/8 | SD | W | 1-0 | Pedro kicks off interleague play with a gem | P. Martinez | Osuna | Foulke | 34-23 | -2.5 |
| 6/9 | SD | L | 1-8 | Nomar returns from injury, goes 1-for-2 | Lawrence | Arroyo | | 34-24 | -3.5 |
| 6/10 | SD | W | 9-3 | Nomar's 2-run double sparks Sox | Schilling | Valdez | | 35-24 | -3.5 |
| 6/11 | LA | W | 2-1 | Manny's error blows Foulke's save; Papi wins it in 9th | Foulke | Martin | | 36-24 | -2.5 |
| 6/12 | LA | L | 5-14 | Wakefield gets hit hard; McCarty pitches the 9th | Weaver | Wakefield | | 36-25 | -3.5 |
| 6/13 | LA | W | 4-1 | Pokey's glovework on display | P. Martinez | Nomo | Foulke | 37-25 | -3.5 |
| 6/15 | at COL | L | 3-6 | Todd Helton and Vinny Castilla lead Rockies | Kennedy | Arroyo | Chacon | 37-26 | -4.5 |
| 6/16 | at COL | L | 6-7 | Late rally not enough | Jennings | Schilling | Chacon | 37-27 | -5.5 |
| 6/17 | at COL | W | 11-0 | 3 hits and 5 RBI for Ortiz | Lowe | Cook | | 38-27 | -4.5 |
| 6/18 | at SF | W | 14-9 | 5 Sox homers win a wild one | Timlin | Williams | | 39-27 | -3.5 |
| 6/19 | at SF | L | 4-6 | Edgardo Alfonzo's HR beats Sox in 8th | Herges | Embree | | 39-28 | -4.5 |
| 6/20 | at SF | L | 0-4 | Sox get only 1 hit off Jason Schmidt | Schmidt | Arroyo | | 39-29 | -4.5 |
| 6/22 | MIN | W | 9-2 | Nomar's grand slam highlights win | Schilling | Lohse | | 40-29 | -4.5 |
| 6/23 | MIN | L | 2-4 | Torii Hunter homers to beat Sox | Silva | Lowe | Nathan | 40-30 | -4.5 |
| 6/24 | MIN | L | 3-4 (10) | Twins beat Foulke in 10th | Balfour | Foulke | Nathan | 40-31 | -5.5 |
| 6/25 | PHI | W | 12-1 | Sox score 8 in 6th; rain ends game in 8th | P. Martinez | Abbott | | 41-31 | -5.0 |
| 6/26 | PHI | L | 2-9 | Jim Thome's 25th HR leads Phillies past Sox | Madson | Arroyo | | 41-32 | -5.0 |
| 6/27 | PHI | W | 12-3 | Schilling wins his 10th game | Schilling | Myers | | 42-32 | -5.5 |
| 6/29 | at NYY | L | 3-11 | Yankees take advantage of Lowe and 3 Sox errors | Vazquez | Lowe | | 42-33 | -6.5 |
| 6/30 | at NYY | L | 2-4 | NY scores 2 in 7th and 2 in 8th to win | Gordon | Timlin | Rivera | 42-34 | -7.5 |
| Date | Vs. | | Score | Summary | WP | LP | SV | Record | GA/GB |
| 7/1 | at NYY | L | 4-5 (13) | Sox drop heart-breaker in 13th as Yankees sweep | Sturtze | Leskanic | | 42-35 | -8.5 |
| 7/2 | at ATL | L | 3-6 (12) | Nick Green's homer in 12th sinks Sox | Cruz | A. Martinez | | 42-36 | -8.5 |
| 7/3 | at ATL | W | 6-1 | Schilling's 10-K CG bails out overworked bullpen | Schilling | Thomson | | 43-36 | -7.5 |
| 7/4 | at ATL | L | 4-10 | Lowe suffers 5th inning meltdown | Hampton | Lowe | | 43-37 | -7.5 |
| 7/6 | OAK | W | 11-0 | Damon has 5 hits as return to Fenway cures Sox | Wakefield | Zito | | 44-37 | -7.0 |
| 7/7 | OAK | W | 11-3 | Ramirez, Garciaparra, and Bellhorn homer | P. Martinez | Redman | | 45-37 | -6.0 |
| 7/8 | OAK | W | 8-7 (10) | Mueller's game-winning double completes the sweep | Leskanic | Lehr | | 46-37 | -6.0 |
| 7/9 | TEX | W | 7-0 | Damon hits 2 homers | Arroyo | Benoit | | 47-37 | -6.0 |
| 7/10 | TEX | W | 14-6 | Sox have 14 runs, 21 hits, 4 homers in Fenway romp | Lowe | Rogers | | 48-37 | -6.0 |
| 7/11 | TEX | L | 5-6 | Foulke tagged with loss | Shouse | Foulke | Cordero | 48-38 | -7.0 |
| 7/13 | AL at NL | 9-4 | A.L. gets home field advantage for World Series as Ramirez and Ortiz homer in All-Star Game win |
| 7/15 | at ANA | L | 1-8 | Lowe gives up 5 in the 5th | Washburn | Lowe | | 48-39 | -8.0 |
| 7/16 | at ANA | W | 4-2 | Nomar homers and Pedro wins 6th straight | P. Martinez | Escobar | Foulke | 49-39 | -7.0 |
| 7/17 | at ANA | L | 3-8 | Vladimir Guerrero strikes again with homer | Colon | Wakefield | | 49-40 | -8.0 |
| 7/18 | at ANA | W | 6-2 | Ortiz triples and homers for Schilling | Schilling | Lackey | | 50-40 | -7.0 |
| 7/19 | at SEA | L | 4-8 (11) | Bret Boone's 11th inning grand slam beats Sox | Myers | Leskanic | | 50-41 | -7.0 |
| 7/20 | at SEA | W | 9-7 | 8-run 4th inning helps Lowe get the win | Lowe | Pineiro | Foulke | 51-41 | -7.0 |
| 7/21 | BAL | L | 5-10 | O's score 8 runs off Pedro | Bedard | P. Martinez | | 51-42 | -8.0 |
| 7/22 | BAL | L | 3-8 | Abe Alvarez makes his ML debut | R. Lopez | Alvarez | | 51-43 | -9.0 |
| 7/22 | BAL | W | 4-0 | In nightcap, Sox finally beat Orioles | Wakefield | Borkowski | | 52-43 | -8.5 |
| 7/23 | NYY | L | 7-8 | Millar's 3 homers aren't enough | Gordon | Foulke | Rivera | 52-44 | -9.5 |
| 7/24 | NYY | W | 10-9 | Tek and A-Rod brawl; Rivera blows save; Mueller's
walk-off homer wins it | Mendoza | Rivera | | 53-44 | -8.5 |
| 7/25 | NYY | W | 9-6 | Sox tag Jose Contreras with 8 runs | Lowe | Contreras | Foulke | 54-44 | -7.5 |
| 7/26 | at BAL | W | 12-5 | Pedro gets early support | P. Martinez | Bedard | | 55-44 | -7.5 |
| 7/28 | at BAL | L | 1-4 | Javy Lopez homers twice to beat Schilling | Borkowski | Schilling | | 55-45 | -8.0 |
| 7/30 | at MIN | W | 8-2 | Each Red Sox starter reaches base | Arroyo | Lohse | | 56-45 | -7.5 |
| 7/31 | at MIN | L | 4-5 | Mientkiewicz goes 2-for-4 for his new team | Rincon | Embree | Nathan | 56-46 | -8.5 |
| Date | Vs. | | Score | Summary | WP | LP | SV | Record | GA/GB |
| 8/1 | at MIN | L | 3-4 | Cabrera has HR and error in 1st game with the Sox | Santana | Timlin | Nathan | 56-47 | -9.5 |
| 8/2 | at TB | W | 6-3 | McCarty's 3-run homer lifts Sox | Wakefield | Hendrickson | Foulke | 57-47 | -9.0 |
| 8/3 | at TB | W | 5-2 | Schilling pitches his 3rd complete game | Schilling | Bell | | 58-47 | -8.0 |
| 8/4 | at TB | L | 4-5 | Roberts thrown out at home in 9th | Harper | Arroyo | Baez | 58-48 | -9.0 |
| 8/6 | at DET | L | 3-4 | Sox fall 10 behind the Yankees in A.L. East | Novoa | Lowe | Urbina | 58-49 | -10.5 |
| 8/7 | at DET | W | 7-4 | Pedro has 10+ K's for 69th time with the Sox | P. Martinez | Bonderman | | 59-49 | -10.5 |
| 8/8 | at DET | W | 11-9 | Wake gives up 7 HR but gets the win | Wakefield | Robertson | Foulke | 60-49 | -10.5 |
| 8/9 | TB | L | 3-8 | Schilling loses his first game at Fenway | Halama | Schilling | | 60-50 | -10.5 |
| 8/10 | TB | W | 8-4 | Bottom of the order drives in all 8 runs | Arroyo | Sosa | | 61-50 | -9.5 |
| 8/11 | TB | W | 14-4 | Millar has 4 hits and 4 RBI | Lowe | Brazelton | | 62-50 | -9.5 |
| 8/12 | TB | W | 6-0 | Pedro pitches complete game shutout | P. Martinez | Hendrickson | | 63-50 | -9.5 |
| 8/13 | CWS | L | 7-8 | Jose Contreras finally beats the Sox | Contreras | Wakefield | Takatsu | 63-51 | -10.5 |
| 8/14 | CWS | W | 4-3 | Ortiz breaks 8th inning tie with 2nd HR of the day | Schilling | Adkins | Foulke | 64-51 | -10.5 |
| 8/15 | CWS | L | 4-5 | Sox strand 12, including 3 in the 9th | Buehrle | Arroyo | Takatsu | 64-52 | -10.5 |
| 8/16 | TOR | W | 8-4 | Mientkiewicz makes 1st career start at 2B | Lowe | Miller | Foulke | 65-52 | -10.0 |
| 8/17 | TOR | W | 5-4 | Cabrera's double off the scoreboard wins it in 9th | Foulke | Frederick | | 66-52 | -9.0 |
| 8/18 | TOR | W | 6-4 | Sox go 15 games over .500 with sweep | Wakefield | Batista | | 67-52 | -8.0 |
| 8/20 | at CWS | W | 10-1 | Sox score 6 in the 1st two innings for Schilling | Schilling | Buehrle | | 68-52 | -7.5 |
| 8/21 | at CWS | W | 10-7 | Manny homers and has 5 RBI | Arroyo | Stewart | Foulke | 69-52 | -6.5 |
| 8/22 | at CWS | W | 6-5 | Manny and Big Papi go back-to-back | Leskanic | Marte | Foulke | 70-52 | -5.5 |
| 8/23 | at TOR | L | 0-3 | Ted Lilly's 3-hitter snaps Sox' streak | Lilly | P. Martinez | | 70-53 | -6.5 |
| 8/24 | at TOR | W | 5-4 | Mirabelli's homer gives Sox the lead | Wakefield | Batista | Foulke | 71-53 | -6.5 |
| 8/25 | at TOR | W | 11-5 | Ortiz homers twice for Schilling | Schilling | Towers | | 72-53 | -5.5 |
| 8/26 | DET | W | 4-1 | Arroyo allows less than 4 earned runs for 11th time | Arroyo | Johnson | Foulke | 73-53 | -5.5 |
| 8/27 | DET | W | 5-3 | Lowe goes 8 innings for the win | Lowe | Maroth | Leskanic | 74-53 | -5.5 |
| 8/28 | DET | W | 5-1 | Pedro moves into top 20 on career strikeout list | P. Martinez | Bonderman | | 75-53 | -5.5 |
| 8/29 | DET | W | 6-1 | Wakefield completes the 4-game sweep | Wakefield | Ledezma | | 76-53 | -4.5 |
| 8/31 | ANA | W | 10-7 | Ramirez passes Jim Rice with 383 career homers | Schilling | Lackey | Foulke | 77-53 | -3.5 |
| Date | Vs. | | Score | Summary | WP | LP | SV | Record | GA/GB |
| 9/1 | ANA | W | 12-7 | Millar homers as division title comes into sight | Adams | Sele | | 78-53 | -3.5 |
| 9/2 | ANA | W | 4-3 | Sox take control of wild card with sweep of Angels | Lowe | Colon | Foulke | 79-53 | -3.5 |
| 9/3 | TEX | W | 2-0 | Pedro brilliant as Sox win 10th straight | P. Martinez | Wasdin | Foulke | 80-53 | -2.5 |
| 9/4 | TEX | L | 6-8 | Streak ends as Michael Young hits 3-run homer | C. Young | Wakefield | Cordero | 80-54 | -2.5 |
| 9/5 | TEX | W | 6-5 | No. 35 by Ortiz backs Schilling | Schilling | Drese | | 81-54 | -2.5 |
| 9/6 | at OAK | W | 8-3 | Manny's defense (and another HR) power Sox | Arroyo | Zito | | 82-54 | -2.5 |
| 9/7 | at OAK | W | 7-1 | Lowe gets 5th straight win | Lowe | Redman | | 83-54 | -2.5 |
| 9/8 | at OAK | W | 8-3 | Pedro allows 2 hits in 6 innings | P. Martinez | Hudson | Foulke | 84-54 | -2.0 |
| 9/9 | at SEA | L | 1-7 | Rookie Bobby Madritsch shuts down Sox | Madritsch | Wakefield | | 84-55 | -3.5 |
| 9/10 | at SEA | W | 13-2 | Schilling 1st pitcher to win 19 games this year | Schilling | Franklin | | 85-55 | -2.5 |
| 9/11 | at SEA | W | 9-0 | Arroyo pitches 7 shutout innings | Arroyo | Moyer | | 86-55 | -2.5 |
| 9/12 | at SEA | L | 0-2 | Gil Meche pitches 5-hit shutout | Meche | Lowe | | 86-56 | -3.5 |
| 9/14 | TB | L | 2-5 | Rookie Scott Kazmir outduels Pedro | Kazmir | P. Martinez | | 86-57 | -4.0 |
| 9/15 | TB | W | 8-6 | Millar and Bellhorn hit 2-run homers | Myers | Nunez | Foulke | 87-57 | -4.0 |
| 9/16 | TB | W | 11-4 | Sox score at least 9 for 5th time for Schilling | Schilling | Hendrickson | | 88-57 | -3.5 |
| 9/17 | at NYY | W | 3-2 | Cabrera and Damon beat Mariano Rivera in 9th | Timlin | Rivera | Foulke | 89-57 | -2.5 |
| 9/18 | at NYY | L | 4-14 | Jon Lieber a surprise star for Yankees | Lieber | Lowe | | 89-58 | -3.5 |
| 9/19 | at NYY | L | 1-11 | Mike Mussina quiets Sox bats | Mussina | P. Martinez | | 89-59 | -4.5 |
| 9/20 | BAL | L | 6-9 | Wakefield loses control in 5-run 4th | Grimsley | Wakefield | Julio | 89-60 | -4.5 |
| 9/21 | BAL | W | 3-2 | Bellhorn's 2-run single in 9th bails out Foulke | Foulke | Ryan | | 90-60 | -4.5 |
| 9/22 | BAL | W | 7-6 (12) | Cabrera homers in 12th for 2nd straight walk-off | Leskanic | Bauer | | 91-60 | -3.5 |
| 9/23 | BAL | L | 7-9 | Papi's bid for walk-off HR caught at warning track | Williams | Mendoza | | 91-61 | -4.5 |
| 9/24 | NYY | L | 4-6 | Flashback: Pedro tires in the 8th | Gordon | P. Martinez | Rivera | 91-62 | -5.5 |
| 9/25 | NYY | W | 12-5 | 7-run 8th breaks a 5-5 tie | Foulke | Quantrill | | 92-62 | -4.5 |
| 9/26 | NYY | W | 11-4 | Schilling shines in Sox' final home game | Schilling | Brown | | 93-62 | -3.5 |
| 9/27 | at TB | W | 7-3 | Sox clinch playoff berth | Arroyo | Sosa | | 94-62 | -3.0 |
| 9/28 | at TB | W | 10-8 (11) | Millar's 11th-inning homer wins it | Mendoza | Baez | Foulke | 95-62 | -2.5 |
| 9/29 | at TB | L | 4-9 | Pedro loses his 4th straight | Waechter | P. Martinez | Miller | 95-63 | -4.0 |
| Date | Vs. | | Score | Summary | WP | LP | SV | Record | GA/GB |
| 10/1 | at BAL | W | 8-3 | Damon and Ortiz give Wakefield his 12th win | Wakefield | R. Lopez | | 96-63 | -3.5 |
| 10/2 | at BAL | W | 7-5 | Subs are enough for a win | Adams | Cabrera | Foulke | 97-63 | -3.0 |
| 10/2 | at BAL | W | 7-5 | Cabrera homers as Sox sweep double header | Kim | Grimsley | Leskanic | 98-63 | -2.0 |
| 10/3 | at BAL | L | 2-3 | Williamson gets the loss | Chen | Williamson | Ryan | 98-64 | -3.0 |
